Tag Archives: CRISPR

Magnanimous

“There is nothing like looking if you want to find something. You certainly usually find something, if you look, but it is not always quite the something you were after.”  J.R.R. Tolkien, The Hobbit

In two of my favorite Oscar winning Peter O’Toole movies he played the same historical figure, Henry II of England. In the first, “Becket,” the young Henry eventually has his former close friend St. Thomas Becket, played by Richard Burton, murdered in the cathedral. Both O’Toole and Burton were nominated for Best Actor for the film. In the second, “Lion in Winter,” late in life, Henry bickers bitterly and poignantly with his exiled wife, Eleanor of Aquitaine, wonderfully portrayed by Katherine Hepburn; they spar brilliantly over succession among the sons Richard the Lionhearted, Jeffrey and John. John, of course, eventually becomes king after the death of Richard and is the villain of the Robin Hood legends. Battles, conspiracies, crusades, and palace intrigue follow all of them all their lives.

King John, devious, adulterous and with a vindictive pettiness that alienated the nobles of the land was forced by the barons to sign the Magna Carta (the Great Charter), a foundational document of the Western world. The king for the first time acknowledges that a king too is subject to the law and that his subjects have rights, including a trial by jury and the beginnings of what evolved into a representative parliamentary form of governance.

“Be afraid only of thoughtlessness and pusillanimity.”  St. Pope John Paul to thousands of young people in Krakow, Poland, June 1979

The word “magnanimous” is a combination of the same Latin root from the Magna Carta, “magnus” or great and “animus,” meaning soul or mind. “Animus” also gives us animated and animal (self-locomotive as opposed to a vegetable). Magnanimous is ‘great souled’ and has come to connote generous and forgiving. A thesaurus gives us noble, benevolent, and altruistic.

“Pusillanimous” is similarly derived from the Latin root “animus,” but the preceding root “pusill” comes from the Latin meaning “very small,” so the combination produces “small minded” or “tiny souled.” Today it has come to mean “lacking determination” or “lacking courage.”  The same thesaurus suggests spineless or cowardly.

Since human beings are uniquely in possession of souls, it matters whether ours are great or tiny. Inextricable from our bodies, we are not ghosts imprisoned in machines. Souls are without material existence, and their fusion with material bodies causes no end of complication and sin, original and actual. Our bodies crave food, comfort, pleasure, protection and retain a controlling drive to propagate other bodies a lot like our own. Our long-suffering souls contend with our material cravings all our short mortal lives seeking wholeness and holiness. Our bodies consist of the same elements that comprise the rest of the universe, forged in the stars and spewed out in vast volume every millisecond of the thirteen billion years of known time. We are spirit and material: stardust and soul.

Pusillanimity and tiny souls seem to govern our public discourse and especially in media, social or otherwise. Whether the ‘cancel culture’ or COVID controversies or environmental crises or proper governance or religion or even what is good for us to eat, our predilection for unreflective rote, rancorous and repetitive talking points in lieu of thoughtful discourse in pursuit of an objective understanding of our perilous situation is disheartening and portends no good outcome.

We have a desperate want for some more great souls: some new beginning with the magnanimous, starting with our own tiny souls and then among our leaders on all sides.

Our ephemeral and ever-changing challenges flood in from every streaming stimuli and seem daunting enough, but that ain’t the half of it. Some recent articles suggest we have more pressing long-term challenges that make COVID, destroying and denying history, neo-Nazi white supremacy, neo-Marxist Black Lives Matter, and defunding police seem like easily resolved minor troubles and soon to be footnotes.

 

“As it will be in the future, it was at the birth of Man

There are only four things certain since Social Progress began,

That the Dog returns to his Vomit and the Sow returns to her Mire,

And the burnt Fool’s bandaged finger goes wabbling back to the Fire…” Rudyard Kipling

 

 To quote the great philosopher Ian Malcolm in the movie “Jurassic Park”: Your scientists were so preoccupied with whether they could, they didn’t stop to think whether they should. Indeed, “should” or “ought” appear to have lost their cache altogether. Moral relativism and a narrow material view of our existence without metaphysics have the podium and the gavel and no inclination to give them up.

One article on Science.com laid waste to the soothing idea that CRISPR technology gene tinkering with human embryos was the work of a single rogue Chinese scientist a couple of years ago. And he conveniently disappeared as inconvenient people tend to do in the People’s Republic. Read CRISPR Gene Editing Prompts Chaos in DNA of Human Embryos about recent experiments on human embryos at the Francis Crick Institute, Columbia University and the Oregon Health and Science Institute. The researchers were concerned that although the experimenters were able to successfully ‘fix’ some troubling genes, there was significant disruption and damage to adjacent gene pairs that were unpredictable in their impact. Maybe future tinkering will make us better at it and avoid the troubling unintended collateral damage? They were careful to point out that there was care and concern that the embryos should not be allowed to develop further into larger specimens of human beings, so destroying them after the experiments was essential. Of course, the underlying assumption that experimenting on undeveloped human beings and destroying them was not particularly morally problematic. We have been destroying human embryos routinely for forty years and calling it woman’s healthcare.

In another article[i] and website[ii], the progressive future of humankind was proposed to offer a way forward to a new perfected kind of human being: immortal, always healthy, more brilliant, and stronger. Perfecting CRISPR was only part of the solution; a hybrid human being with some experiments already underway for embedding chips providing us with ready-made super memories crammed full of immediate access to all manner of useful information. Combined with corrected genes helping to make the vexing protoplasm portion of the mix more perfect, we will create a progressive vision of human perfectibility and utopian society. We have tried this many times with murderous results, but we will get it right this time[iii].  Our future children will have just cause to sue parents who do not optimize their genes when they had the chance in the Petrie dishes prior to implantation.

[iv]“Brave New World” is an anodyne fairy tale compared to this. Tilt back the recliner, make some popcorn, pour a cold beer and watch “Jurassic Park” or “Young Frankenstein” for some laughs.  Maybe listen to Ian Malcolm again.

Or pray for a return of a magnanimous, courageous, and determined moral leadership.

“Look not in the face of the fire, O man! Never dream with your hand on the helm! Turn not your back to the compass…” Herman Melville, Moby Dick

[i] Give “Covid-19 Is Accelerating Human Transformation—Let’s Not Waste It: The Neobiological Revolution is here. Now’s the time to put lessons from the Digital Revolution to use.” a quick read.

[ii] The futurist idealists have a perfected super race in mind for us. I think we may have seen this before, perhaps in mid twentieth century Germany. Browse this site or buy the book if you want and see what they have in store for us: 25 Visions for the Future of Our Species.

[iii] The overly familiar line about not forgetting history because we will be doomed to repeat it is often misattributed to Winston Churchill. It originated with the Spanish-American philosopher George Santayana in “The Life of Reason, Volume 1.” In context, Santayana cautions us that retention of learning is necessary, as is “plasticity” to use that learning to adapt to new situations. When we are young, the tendency is to radical intemperate change without considering the wisdom of the past. And when we are old, the tendency is to hold on too rigidly and not be open to self-criticism, reflection, and necessary beneficial change. The ideal is mature adulthood with a balance of both he states.

Churchill was less optimistic that we learned our lessons. In a 1936 speech to the House of Commons, he warns of the coming cataclysm: When the situation was manageable it was neglected, and now that it is thoroughly out of hand we apply too late the remedies which then might have effected a cure.

 

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CRISPR Critters

“I don’t know how it will be in the years to come. There are monstrous changes taking place in the world, forces shaping a future whose face we do not know.” East of Eden, John Steinbeck

We have recently taken the plunge having long ago resigned ourselves to the reality that there is no privacy anymore. Spitting into a tube and mailing it off to 23 Ancestry, our DNA sequence has been typed and available for analysis. Among the findings on me was that I have deep in my genome a tiny percentage of Italian and Portuguese ancestry. No longer can Rita lay sole claim to a Mediterranean heritage. Our DNA sequences will join millions of others cataloged in servers and can be used for everything from medical research, predicting potential health risks and tracking ethnic backgrounds to catching criminals.

DNA databases have been subpoenaed and used to close some old cold cases, including catching a 1973 serial killer, Joseph DeAngelo. Mr. DeAngelo hadn’t even been typed, but his relatives had, and when investigators interviewed the relatives, Mr. DeAngelo figuratively and literally came under the microscope. The investigative team subpoenaed a DNA sample from him in a decades old hunt for the killer. He came up 99.99 percent as the guy. More than likely, he’s breathed the last free air of his life.

A caution about our well tracked future is whether genetic markers would make their way to health insurance providers, or in some Brave New World, whether these indicators could be used to hike premiums for those with certain predispositions. Or worse, deny coverage entirely. May already be happening beneath the radar. This will be adjudicated, precedent established, and hysterical editorials will be written. Count on it.

“Come senators, congressmen
Please heed the call
Don’t stand in the doorway
Don’t block up the hall
For he that gets hurt
Will be he who has stalled.“ 

The Times They Are A-Changin,’ Bob Dylan

Chinese researcher, He Jiankui, wanted to find a cure for HIV AIDS, surely a positive pursuit. He developed a new vein to explore. Why not, instead of curing the disease, make people who cannot get it? He hypothesized the way to do that was to alter a specific gene, CCR5. Using CRSPIR[i] technology on an embryo, he cut and pasted, then implanted tiny humans in a willing (or not) uterus and grew some people. He grew two — twin girls and maybe a third later. Once the word leaked to the international press that He was altering the DNA in genes and making designer babies, the Chinese government reacted with righteous horror, as did many. The government claimed that it was not aware of the extent of his tinkering, and that no authorization was given to implant the babies, only to grow them awhile, see what happens and kill them. He must have saved up his milk money and found some other dark funding for his enterprise. There was even talk of capital punishment for He Jiankui, not an uncommon solution to an embarrassment in China. Last week credible evidence was found by other scientists looking at grant studies that there was Chinese government funding for his research from the start, all of it. Color me surprised. Once a method of customizing human beings is perfected, can Superman soldiers be far behind? Or IQs exceeding 300? Or mutant tireless and uncomplaining laborers? Or any number of permutations of designer people? How will science ethics hold fast with trillions of dollars were at stake? Aldous Huxley writ large. The commodification of human beings continues apace.

Last week another story ran that Crispr Therapeutics and its partner Vertex Pharmaceuticals[ii] had treated a rare blood genetic disease, beta thalassemia, with a one-time application of a CRISPR invader. More trials with human beings and unintended consequences be damned. The same team has started a similar study for sickle cell anemia, a genetic plague that is especially deadly in the African American community. The shares of both companies soared. A new world is upon us, and riches are there for the brave of heart. What could possibly go wrong with purposeful, profitable tweaking of the basic building blocks of human life? Not with a bang, but a whimper.

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I had a dream — a murky vision — of emerging after a long walk in a desolate wood – gnarled ancient trees without leaves – and coming upon a clearing with a dried-up spring and an abandoned house with weathered wood plank walls and a door partially ajar hanging off just the bottom hinge. With some difficulty I pushed through the door and found only a scarred pine table and a tipped over ladder-back chair. On the table were a stale crust of bitten bread, a few broken crayons, a half-burned candle fixed in wax and yellowed books with bent back pages. A story I’ll never know.

‘Twas in another lifetime, one of toil and blood

When blackness was a virtue the road was full of mud

I came in from the wilderness, a creature void of form

Come in, she said

I’ll give ya shelter from the storm.  Shelter From the Storm, Bob Dylan

[i] CRISPIR is the acronym for “clusters of regularly interspaced short palindromic repeats.” It is powerful and terrifying tool that mimics how a type of bacteria ‘learns’ to recognize and defend against a virus. In the bacteria, the “remembered” RNA sequence cuts the DNA of a virus it has learned to defend against into pieces, rendering it harmless. The new technology uses specific RNA sequences to cut and replace targeted sequences of DNA in a cell, including an embryo, and “fixes” or otherwise alters that embryo’s DNA, its chromosomes, its genes, what makes it, it.

[ii] https://finance.yahoo.com/news/crispr-infuses-first-human-landmark-132242277.html

 

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